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jdfi1dd4jf
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Joined: Apr 17 2013 Location: United Kingdom Online Status: Offline Posts: 61 |
![]() Topic: MBT Scarpe Outlet Italia hanno trovato molti geniPosted: May 03 2013 at 6:05am |
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proteiche del complesso. In altre parole, il cancro del pancreas di una persona può avere una mutazione o delezione in una subunità di proteine, mentre un altro potrebbe avere un cambiamento in una subunità diversa. Considerato singolarmente, ogni variazione si verifica relativamente di rado.Shain e Pollack usato una tecnica chiamata ibridazione genomica comparativa array o CGH, per individuare luoghi nel genoma che differiva tra le cellule pancreatiche normali e tumorali epiteliali. La procedura si basa sulla capacità di DNA a singolo filamento per cercare e si legano alla sua immagine speculare. Confrontando le quantità relative di DNA tumorale e normale che si legano ad un pannello di sequenze di riferimento MBT Scarpe Outlet Italia, i ricercatori possono dire se la cella contiene cancro amplificazioni o delezioni di materiale genetico in regioni specifiche di tutto il genoma. Queste variazioni di numero di copia spesso si verificano in geni o regioni importanti nella regolazione della crescita incontrollata delle cellule.I ricercatori hanno esaminato circa 70 tumori pancreatici diversi MBT Scarpe, tra cui i campioni forniti dai loro co-autori presso il Centro di ricerca sul cancro del pancreas Sol Goldman presso la Johns Hopkins University School of Medicine. Quarantotto dei tumori erano campioni da pazienti umani che erano stati forzati a crescere in topi immunodeficienti mtb scarpe prezzi, 22 era stato mantenuto come cancro linee cellulari coltivate in laboratorio. Shain utilizzato ad alta densità array di sequenze di DNA di riferimento per la CGH, che gli ha permesso di identificare le regioni amplificate o eliminati con una risoluzione molto più elevata rispetto al passato - restringendo le aree di interesse a solo poche migliaia di nucleotidi, piuttosto che grandi tratti di DNA . Quando i ricercatori hanno esaminato i risultati delle analisi CGH array, hanno trovato molti geni noti per essere coinvolti nel cancro del pancreas, e anche alcuni nuovi candidati. In particolare, hanno notato che i geni per le singole unità di SWI / SNF complesso sono sta
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fhghfghf
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Joined: Mar 28 2013 Location: United Kingdom Online Status: Offline Posts: 384 |
![]() Posted: May 03 2013 at 3:25pm |
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